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Cannabis is one of the 50 “fundamental” herbs in traditional Chinese medicine. Delta-9-THC is the primary molecule responsible for the effects of cannabis. Delta-9-THC is metabolized in the liver and turns into 11-OH-THC.11-OH-THC is the first metabolic product in this pathway. The metabolism of THC into 11-OH-THC plays a part in the heightened psychoactive effects of edible cannabis. The National Institute on Drug Abuse defines medical cannabis as “using the whole, unprocessed marijuana plant or its basic extracts to treat symptoms of illness and other conditions”. The store also prioritizes cannabis education, making a special effort even on the web page to answer a whole host of questions that might be on the minds of concerned consumers.
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The American Medical Association and American College of Physicians do not take a position on the legalization of medical cannabis, but have called for the Schedule I classification to be reviewed. The American Academy of Family Physicians and American Society of Addiction Medicine also do not take a position, but do support rescheduling to better facilitate research. Cannabis began to attract renewed interest as medicine in the 1970s and 1980s, in particular due to its use by cancer and AIDS patients who reported relief from the effects of chemotherapy and wasting syndrome. In 1996, California became the first U.S. state to legalize medical cannabis in defiance of federal law. In 2001, Canada became the first country to adopt a system regulating the medical use of cannabis. Medical cannabis can be administered through various methods, including capsules, lozenges, tinctures, dermal patches, oral or dermal sprays, cannabis edibles, and vaporizing or smoking dried buds.
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In 1850 cannabis was entered into the United States Pharmacopeia. An anecdotal report of Cannabis indica as a treatment for tetanus appeared in Scientific American in 1880. Cannabis, called má 麻 (meaning “hemp; cannabis; numbness”) vape pen or dàmá 大麻 (with “big; great”) in Chinese, was used in Taiwan for fiber starting about 10,000 years ago. He recommended the substance for many ailments, including constipation, gout, rheumatism, and absent-mindedness.
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“Dà má” is the Chinese expression for cannabis, the first character meaning “big” and the second character meaning “hemp”. There are approximately 16 landrace strains of cannabis identified from Pakistan, Jamaica, Africa, Mexico, Central America and Asia. Similar to THC, CBD has poor oral bioavailability, approximately 6%. The low bioavailability is largely attributed to significant first-pass metabolism in the liver and erratic absorption from the gastrointestinal tract.
O’Shaughnessy discovered cannabis in the 1830s while living abroad in India, where he conducted numerous experiments investigating the drug’s medical utility . He returned to England with a supply of cannabis in 1842, after which its use spread through Europe and the United States. In 1845 French physician Jacques-Joseph Moreau published a book about the use of cannabis in psychiatry.
Once a month, recreational marijuana users can purchase 30 g of dried marijuana. Medical cannabis users can have a prescription for a certain amount of dried weed per month. Smoking has been the means of administration of cannabis for many users, but it is not suitable for the use of cannabis as a medicine. It was the most common method of medical cannabis consumption in the US as of 2013. The potential for adverse effects from smoke inhalation makes smoking a less viable option than oral preparations. Cannabis vaporizers have gained popularity because of a perception among users that fewer harmful chemicals are ingested when components are inhaled via aerosol rather than smoke.
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